Endocrine Abstracts

Adrenal rest tumours are well described in 21-hydroxylase deficiency but less frequently in 11-β hydroxylase (11-β OH) deficiency. We report a case with an established diagnosis of 11-β OH deficiency with non-compliance to steroid treatment and endocrine follow-up.He presented to Urology with haemospermia.He was found to have scrotal swellings. Ultrasound confirmed bilateral testicular tumours.CAT scan showed small para-aortic lymph nodes ...

Thyroid hormone is absolutely necessary for early brain development. Incidence of thyroid disorders in infancy is 1:4,000. Thyroid hormones can be deficient through hormone synthesis and action or very rarely through defective transport. Some new and exciting transporters for tri-iodothyronine (T3) have recently come to light. MCT 8 gene encodes the protein that transports T3 into neurons. Its mutation result in inability of T3 to enter a devel...